Archive for April, 2012
By Jennifer Morganti, ND, Director of Education for NEEDS
Uridine may not be an ingredient that is commonly found in dietary supplements, but research shows promising results that may change that fact. Uridine-5′-Monophosphate (UMP) specifically, is one of the basic building blocks for RNA and DNA, the foundations for our genetic coding. UMP also combines with omega-3 fatty acids (DHA and EPA) and choline to produce the membrane of brain cells and ultimately promote nerve growth, nerve protection, and nerve communication. Clinical trials have shown that combining these three nutrients may improve cognitive function, particularly memory and learning.
A study published in 2010 evaluated the effects of a medical food that contains UMP, omega-3 fatty acids, and choline on cognitive function in 225 people with mild Alzheimer’s disease. Patients were randomized to take the formula or placebo for 12 weeks and were given various cognitive function tests at the beginning and end of the trial. The group taking the formula was found to have significantly improved one particular cognitive function, that being verbal recall (memory), as compared to the placebo group, which experienced no significant improvements.
An animal study also demonstrated that the combination of UMP, DHA, and choline raised phosphatidyl choline (PC) levels, which is the major lipid in nerve membranes and promotes nerve growth.