Archive for September, 2012
As you grow older, age-related stiffness and discomfort in the joints becomes a fact of life. Activities once routine become a challenge as limited mobility hampers your every move. You now have a more potent option to provide broad-spectrum support for aging joints. ArthroMax™ Advanced with UC-II® and AprèsFlex™ is a multi-nutrient formula based on the very latest data on natural support for joint health. The new ArthroMax™ formula provides more joint support than ever before, enhanced with two innovative, clinically validated ingredients: AprèsFlex™ and UC-II®.
AprèsFlex™ represents a quantum leap forward in the delivery to aging joints of boswellia, long prized for its ability to help with inflammatory issues. It is a superior inhibitor of the enzyme 5-lipoxygenase or 5-LOX. Excess activity of 5-LOX results in the accumulation of leukotriene B4, a proinflammatory compound that affects aging joints. Boswellia has been shown to bind directly to the 5-LOX enzyme, preventing it from facilitating production of pro-inflammatory leukotrienes. (46,47) AprèsFlex™ boswellia absorbs into the blood 52% better than previously available forms of boswellia, for superior effectiveness.
In addition to AprèsFlex™, this new ArthroMax™ contains a novel standardized chicken cartilage: UC-II®. New data shows it helps with immune issues that can impact joint discomfort and ease of motion in aging individuals.
Taken orally, UC-II® travels to the intestinal tract where it “introduces” the immune system to the same type of collagen molecules found in joint cartilage.
Not just any form of collagen will do. Normally, when chicken collagen is processed, its molecular shape is changed. It loses bioactivity and becomes denatured—which researchers found has no beneficial effect (2) on the immune system. Fortunately, a unique processing technique preserves the correct molecular shape of the collagen (3,4) and preserves its bioactivity (5)—producing a form known as undenatured collagen. The result of this innovative process is an undenatured chicken collagen called Bio-Collagen with Patented UC-II®.
Scientific studies have found that UC-II® reduced sensitive joint discomfort and eased joint function. (1,6-10) One double-blind, placebo-controlled study on patients found that UC-II® provided relief by 33%, and decreased joint discomfort scores by a remarkable 40% in just 90 days.(1)
1. Int J Med Sci. 2009;6(6):312-21. 2. Proc Natl Acad Sci U S A. 1986 Oct;83(19):7443-6. 3. Int Immunopharmacol. 2011 Jan;11(1):12-8. 4. Int J Clin Pharmacol Res. 2002;22(3-4):101-10. 5. Immunol Rev. 2005;206:232-59. 6. J Vet Pharmacol Ther. 2005 Aug;28(4):385-90. 7. J Vet Pharmacol Ther. 2007 Jun;30(3):275-8. 8. Toxicol Mech Methods. 2007;17(4):189-96. 9. J Anim Physiol Anim Nutr (Berl). Epub 2011 May 30. 10. J Vet Pharmacol Ther. 2009 Dec;32(6):577-84. 46. Wien Med Wochenschr. 2002;152(15-16):373-8. 47. J Ethnopharmacol. 2006 Sep 19;107(2):249-53.
Copyright © 2012. All rights reserved. Reprinted with exclusive permission of Life Extension Magazine
Lavender, an herb long prized for its pleasing fragrance, is also an effective remedy for anxiety. Taken orally, lavender extract can be as effective as some of the conventionally prescribed alternatives. Lavender has been used, both internally and by aromatherapy, for centuries for anxiety and depression, as well as for insomnia and gastrointestinal distress (Greive, 1931). Modern analytical methods show more than 160 constituents, many of which interact synergistically to contribute to lavender’s healing effects (Cavanagh et al, 2002).
Clinical Trials of Oral Lavender
Although much previous research on lavender was on its effects when administered as aromatherapy, two controlled clinical trials of have explored the effects of oral, pharmacopoeia-grade lavender oil on anxiety.
Kasper and colleagues compared lavender oil (WS® 1265) against placebo for anxiety in 221 adults from 21 primary care or psychiatric practices. (Kasper et al, 2010). Subjects took 80 mg of lavender oil or placebo for 10 weeks. Those taking lavender showed a total reduction in anxiety scores decrease of 16 points versus 9.5 points for those taking placebo. The lavender was also superior to placebo in terms of having more people respond and fewer people relapse.
In another study, researchers compared lavender oil (WS®1265) to a low-dose, commonly prescribed anti-anxiety drug. (Woelk & Schlafke, 2010) The lavender oil, a steam distillate of Lavandula angustifolia, decreased mean anxiety total scores by 45%, versus 46% in the drug group. At the conclusion of the trial, 40% of the lavender group and 27% of the drug group met criteria for remission; the lavender group had a response rate of 52.5% compared to 40.5% of those on the drug.
Lavender oil products for oral use should comply with the most stringent quality standards, such as those set forth in the European Pharmacopoeia. When in compliance with or exceeding these standards, and used at the recommended dose, there is no reason to expect any significant adverse effects. As a precaution, oral lavender oil is not recommended for children only because there are insufficient data available pertaining to this use. Unlike commonly prescribed anti-anxiety drugs, for example, lavender does not cause psychological or chemical dependence.
Kasper S, et al. Int Clin Psychopharmacol 2010; 25:277–87
Woelk H, Schlafke S. Phytomedicine Int J Phytotherapy Phytopharmacol 2010; 17:2: 94–99.
Blumenthal M, ed. Lavender flower. In: The Complete German Commission E Monographs. Austin, TX: American Botanical Council; 1998:159–60.
Bio: Jeremy Appleton, ND is a licensed naturopathic physician with an extensive background in natural medicine and education. He graduated from National College of Natural Medicine (NCNM), and did his residency at Bastyr University, where he was also on faculty. He served as chair of the nutrition department chair at NCNM for 5 years. He has lectured extensively around the world on topics in nutrition, botanical medicine and dietary supplement quality issues. He is currently Director of Scientific Affairs at Integrative Therapeutics.